Research Summary
Dr. Bingham目前的研究主要集中在通过更精确的疾病表型来改善对炎症性关节炎患者的评估, 从生化表征到测量个体患者水平的疾病经历和环境因素. 这项工作利用综合临床和研究操作和基础设施,将调查与临床护理结合起来.
Dr. Bingham指导了许多研究项目:(1)通过开发和测试患者报告的结果测量来改善对炎症性关节炎患者观点的评估.g. PROMIS); (2) Developing and improving methods to evaluate novel immunomodulatory therapies and treatment strategies; and (3) Evaluating the role of oral inflammation as a disease initiating or amplifying factor in RA;. 其他正在进行的合作项目是评估成像RA和OA的先进技术和分子诊断, 关节炎疼痛的机制和介质, 新型生物工程化合物和干细胞可以减少炎症,潜在地促进关节修复.
Clinical Trial Keywords
Rheumatoid arthritis, clinical trials, outcome measures, patient-reported outcomes, psoriatic arthritis, spondyloarthritis, patient centered outcomes research
Clinical Trials
http://www.hopkinsarthritis.org/arthritis-research/
http://www.hopkinsarthritis.org/arthritis-research/patient-centered-outcomes-research/understanding-patient-centered-outcomes-research/
http://www.hopkinsarthritis.org/arthritis-research/clinical-trials/
Selected Publications
View all on PubMed
Orbai AM, Smith KC, Bartlett SJ, DeLeon E, Bingham CO 3. “我认为,僵硬对每个人都有不同的含义.“从类风湿关节炎患者的角度研究僵硬. Arthritis Care Res (Hoboken). 2014 Nov; 66(11):1662-72. PMID: 24891304.
Bartlett SJ, Bykerk VB, Cooksey R, Choy EH, Alten R, Christensen R, Furst DR, Guillemin F, Halls S, Hewlett S, Leong AL, Lyddiatt A, March L, Monte P, Orbai AM, Pohl C, Voshaar MS, Woodworth TG, Bingham CO 3rd. RA耀斑核心域集的可行性与域验证:OMERACT耀斑工作组报告. J Rheumatol 2015 Feb 15. pii: jrheum.141169. [Epub 2015 Feb 15] PMID: 25684764.
Bingham CO 3rd, Alten R, DeWit MP. 患者参与测量类风湿关节炎发作的重要性. Ann Rheum Dis, 2012;71:7 1107-1109. (Invited Editorial). PMID: 22323439.
Boers M, Kirwan JR, Wells G, Beaton D, Gossec L, D’Agostino MA, Conaghan PG, Bingham CO 3rd, Brooks PB, Landewe R, March L, Simon LS, Singh JA, Strand V, Tugwell PT. 开发临床试验的核心结果测量集:OMERACT Filter 2.0. J Clin Epi 2014 Jul;67(7):745-53. PMID: 24582946
McMahan ZH, Bingham CO 3rd. 生物和非生物免疫调节疗法对风湿病患者疫苗免疫原性的影响. Arthritis Res Ther 2014; 16:506 doi:10.1186/s13075-014-0506-0. PMID: 25587634.
Bingham CO 3, Rizzo W, Kivitz A, Hassanali A, Upmanyu R, Klearman M. 托珠单抗治疗的类风湿关节炎患者对疫苗的体液免疫反应:一项随机对照试验的结果(VISARA). Ann Rheum Dis 2015; 74:818-822.[Epub 21 Jan 2014]. PMID: 2448345.
Winthrop KL, Silverfield J, Racewicz A, Neal J, Lee EB, Hrycaj P, Gomez-Reino J, Soma K, Riese R, Mebus C, Wilkinson B, Hodge J, Fan H, Wang T, Bingham CO 3rd. 托法替尼对类风湿关节炎患者肺炎球菌和流感疫苗应答的影响. Ann Rheum Dis 2015 March 20, doi:10.1136/ annrheumatis -2014-207191 [Epub 2015年3月20日]. PMID: 5795907.
Orbai AM, Bingham CO 3rd. 类风湿关节炎患者报告的预后. Curr Rheumatol Rep. 2015 Apr;17(4):501. doi: 10.1007/s11926-015-0501-8. (Invited Review).PMID: 25854489.
Bartlett SJ, Haaz S, Mill C, Bernatsky S, Bingham CO 3. Yoga in rheumatic diseases. 中华风湿病杂志,2013;15(12):387. (Invited Review). PMID: 24173693.
Moonaz SH, Bingham CO 3, Wissow L, Bartlett SJ. 瑜伽对久坐成人关节炎的治疗:一项随机对照实用试验的效果. J Rheumatol Jul;42(7):1194-202. doi: 10.3899/jrheum.141129. Epub 2015 Apr 1. PMID: 25834206.
Timlin H, Bingham CO 3rd. 类风湿性关节炎生物制剂分子结构的有效性和安全性. 专家意见,2014;14(7):893-904. (Invited Review). PMID: 24720727.
Patient Ratings & Comments
患者评分分数是通过Press Ganey对全国CG-CAHPS医疗实践患者体验调查中与医生相关问题的所有回答的平均值. 回答以1到5分进行衡量,5分是最高分. 我们还通过Press Ganey收集了CG-CAHPS医疗实践调查的评论,并将其完整地展示出来. 出于保密和患者隐私的考虑,患者的身份被取消.